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Fig. 2 | Genome Biology

Fig. 2

From: Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism

Fig. 2

DNA methylation changes in the aging mouse liver. a Beanplot representation of global DNA methylation levels in the liver of young and old ad libitum-fed (AL) and dietary restriction (DR) mice (n = 1,167,959 bins). Solid lines represent group-wise means; density curves were scaled. b Number of significantly differentially methylated regions (DMRs) (p < 0.05, ±10% < DNA methylation difference) between young and old mice under AL and DR conditions. c Functional enrichment of age-related differentially hyper- and hypomethylated genes. d Density scatter plot of age-related DMRs indicating the magnitude of DNA methylation changes with respect to the methylation level in young AL mice. Lines indicate median of methylation levels for hypo- and hypermethylated DMRs

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