Skip to main content
Fig. 5 | Genome Biology

Fig. 5

From: Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions

Fig. 5

Ames dwarf mice are resistant to cancer-like methylation changes during aging. a Mean methylation enrichment per probe (top panel) at all probes within enhancers that contain WT hypomethylated aDMRs, for control (x-axis) and Mdr-2 knockout (KO; y-axis) mice. Numbers at top left and bottom right show the number of probes above and below the dashed diagonal. The bottom panel shows the same data per mouse replicate. *P < 0.05 (two tailed t-test). b As a but using enhancers containing WT hypermethylated aDMRs. **P < 0.01 (two tailed t-test). c As a but using bivalent regions that contain WT hypermethylated aDMRs. **P < 0.01 (two tailed t-test). d As a but using enhancers that contain Ames dwarf hypomethylated aDMRs. P > 0.05 (two tailed t-test). e As a but using enhancers that contain Ames dwarf hypermethylated aDMRs. **P < 0.01 (two tailed t-test). f As a but using bivalent regions that contain Ames dwarf hypermethylated aDMRs. **P < 0.01 (two tailed t-test)

Back to article page

Genome Biology

ISSN: 1474-760X

Contact us