Fig. 3
From: IRFinder: assessing the impact of intron retention on mammalian gene expression
IR marks stages of cell differentiation and the cell cycle. a IR measured during 4 days of overexpression of Neurogenin-1 and -2 to differentiate human embryonic stem cells (hESCs) into bipolar neurons [16]. b IR and mRNA expression of two crucial genes, SOX15 and POU4F1. c Heatmap of IR measured during differentiation of fibroblasts from genetically matched hESC and human induced pluripotent stem cells (hiPSC) lines. Left: hESCs were grown in extended culture then differentiated into fibroblasts. Right: hESCs are differentiated to fibroblasts, then dedifferentiated to hiPSCs and then differentiated again into fibroblasts. Curly brackets indicate replicates. d Gene Ontology (GO) functional category enrichment after Benjamini–Hochberg (BH) correction. EGF epidermal growth factor. e IR measured for TH2 cells sorted at different stages of the cell cycle. f GO functional category enrichment after BH correction