Skip to main content
Fig. 2 | Genome Biology

Fig. 2

From: MeDeCom: discovery and quantification of latent components of heterogeneous methylomes

Fig. 2

Testing MeDeCom on simulated and artificial cell mixture data. af Results for the simulated data example with five methylation components, moderately variable mixing proportions, and medium noise level. a Selection of parameters k and λ by cross-validation. b Matching of the recovered LMCs to the true underlying profiles. The dendrogram visualizes the agglomerative hierarchical clustering analysis with correlation-based distance measure and average linkage. cf Recovery of the mixing proportions. Truth stands for true mixing proportions and regression denotes the reference-based proportion estimation as described in “Methods.” In each line plot, the synthetic samples are sorted by ascending true mixing proportion. g, h Results for the ArtMixN data set. g Selection of parameters k and λ by cross-validation. h Recovery of mixing proportions (only NeuN + is shown) for MeDeCom and RefFreeCellMix. RefFreeCellMix misinterprets the most extreme mixtures as pure cell types and, thus, estimates T (see Fig. 1b) as well as the proportions in A wrongly. Notation is the same as in cf

Back to article page