Fig. 2From: MeDeCom: discovery and quantification of latent components of heterogeneous methylomesTesting MeDeCom on simulated and artificial cell mixture data. a–f Results for the simulated data example with five methylation components, moderately variable mixing proportions, and medium noise level. a Selection of parameters k and λ by cross-validation. b Matching of the recovered LMCs to the true underlying profiles. The dendrogram visualizes the agglomerative hierarchical clustering analysis with correlation-based distance measure and average linkage. c–f Recovery of the mixing proportions. Truth stands for true mixing proportions and regression denotes the reference-based proportion estimation as described in “Methods.” In each line plot, the synthetic samples are sorted by ascending true mixing proportion. g, h Results for the ArtMixN data set. g Selection of parameters k and λ by cross-validation. h Recovery of mixing proportions (only NeuN + is shown) for MeDeCom and RefFreeCellMix. RefFreeCellMix misinterprets the most extreme mixtures as pure cell types and, thus, estimates T (see Fig. 1b) as well as the proportions in A wrongly. Notation is the same as in c–f Back to article page