Fig. 1From: Functional implications of Neandertal introgression in modern humansFunctional impact of Neandertal non-synonymous alleles. Left: Average PolyPhen2 scores for archaic non-synonymous alleles in East Asians, South Asians, and Europeans (red squares). These averages are compared to averaged Polyphen2 scores for 1000 frequency matched sets of non-archaic non-synonymous alleles (yellow, orange, and brown violin plots). Polyphen2 scores range from 0–1 with higher scores associated with increased deleteriousness. Right: Average SIFT scores for archaic non-synonymous alleles in East Asians, South Asians, and Europeans (red squares). These averages are compared to averaged SIFT scores for 1000 frequency matched sets of non-archaic non-synonymous alleles (yellow, orange, and brown violin plots). SIFT scores range from 0–1 with lower scores associated with increased deleteriousnessBack to article page