TY - JOUR AU - Dannemann, Michael AU - Prüfer, Kay AU - Kelso, Janet PY - 2017 DA - 2017/04/03 TI - Functional implications of Neandertal introgression in modern humans JO - Genome Biology SP - 61 VL - 18 IS - 1 AB - Admixture between early modern humans and Neandertals approximately 50,000–60,000 years ago has resulted in 1.5–4% Neandertal ancestry in the genomes of present-day non-Africans. Evidence is accumulating that some of these archaic alleles are advantageous for modern humans, while others are deleterious; however, the major mechanism by which these archaic alleles act has not been fully explored. SN - 1474-760X UR - https://doi.org/10.1186/s13059-017-1181-7 DO - 10.1186/s13059-017-1181-7 ID - Dannemann2017 ER -