Fig. 3

The proportion and number of sites of cell type-specific methylation in adipose tissue, naïve T cells (nTC), and whole blood (WB). The red segments at the top show the proportion of CpGs that are specific to the specific tissue, and the purple segments at the bottom show the proportion of CpGs that were found in all three cell types. The yellow, green and blue bars show CpGs that are shared between the specific cell type and adipose tissue, naïve T cells, and whole blood, respectively. Shown is the breakdown in the three cell types for a significant mQTL CpGs (q < 0.1), b significant ASM CpGs (q < 0.1), c putative epigenetic (filtered for ASM and mQTL q > 0.1) GIT CpGs (GIT q < 0.01). d Enrichment GWAS SNPs associated with significant ASM in three different tissues—naïve T cells (TC, blue), whole blood (WB, green) and visceral adipose tissue (VAT, red). We show enrichment for disease-associated loci from eight different traits (celiac disease, Crohn’s disease (CD), inflammatory bowel disease (IBD), ulcerative colitis (UC), multiple sclerosis (MS), rheumatoid arthritis (RA), type 1 diabetes (T1D), and type 2 diabetes (T2D)) and SNPs associated with ASM