Fig. 6

Performance analysis in presence of allele drop-outs. Effect of presence of allele drop-outs (ADO) on V-measure index (panel a) and mean absolute error of cellular prevalences (panel b) across multiple values for the total number of single cells (specified as m on top of each panel). Each box plot represents 10 simulated datasets each with 10 genotypes and 48 genomic loci. The cells are sampled from a multinomial distribution with a sample size of m and parameters equal to the true prevalence of each genotype. As expected, progressively increasing the ADO rate results in degrading performance in both clustering and cellular prevalence estimates. The detrimental effect dampens as the number of sampled cells increases