Fig. 2

Simulated phylogenetic tree (panel a) and the resulting binarized cell genotype matrix (panel b). Transposed binarized simulated cell genotypes Δ from Generalized Dollo process over a fixed phylogeny. The original cell genotype matrix Δ ^CN is in copy number space. We binarize it by setting entries with non-zero variant allele copy number to one (coloured red) and setting entries with variant allele copy number of zero to zero (coloured blue). The clonal prevalence of each genotype is in parentheses