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Fig. 12 | Genome Biology

Fig. 12

From: ddClone: joint statistical inference of clonal populations from single cell and bulk tumour sequencing data

Fig. 12

Hypothesized sitting arrangement in ddCRP/subpopulation assumptions in the bulk data. a Induced table sitting T(C) by a particular customer connection configuration C. Bold arrows show customer connections and dotted arrows point to equivalent table sittings. Since customer 7 only has a self-loop, the corresponding table has only one customer. b Our assumption about clonal architecture in the tumour with respect to a particular genomic locus. In this example, normal subpopulation represents a collection of un-mutated diploid cells. Reference subpopulation comprises cells that have a copy number amplification event, but no single nucleotide mutations. Variant subpopulation is a collection of cells that have an SNV at the particular genomic locus

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