Fig. 5
From: Chrom3D: three-dimensional genome modeling from Hi-C and nuclear lamin-genome contacts
Differential radial positioning of TADs associated with peripheral and nucleoplasmic LMNA mutants. a ChIP-seq profiles (log(ChIP/input)) and corresponding LADs for flag-tagged LMNA wt, Flag-LMNA(L647R), Flag-LMNA(R388P), and endogenous LMNA in HeLa cells. b Venn diagram analysis of LAD overlaps (in Mb). c Radial distribution of TADs associated with Flag-LMNA wt, Flag-LMNA(L647R), and Flag-LMNA(R388P) across 400 structures modeled for each LMNA construct. d TADs associated with LMNA wt, LMNA R388P, or LMNA L647R (colored beads) superimposed onto all TADs (gray beads) in a modeled HeLa nucleus. e Immuno-localization of Flag-LMNA proteins and quantification of localization patterns (graph; > 300 nuclei per condition). f Gene density within indicated LADs and in the whole human genome. g LAD size distribution; *P < 2.2 × 10–16 (Mann–Whitney U tests)