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Table 3 Number of independent, significant pairs validated in previous studies

From: Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies

Pair type

Comparison study

Eligible lead eQTL-gene pairsa

Validated pairsa (rate)

Expected pairs (rate)

Cis

Multiple studies [2, 46]

10,584

5700 (54%)

90 (0.8%)

Battle et al. [7]

11,466

2911 (25%)

10 (0.08%)

Kirsten et al. [8]

11,179

6503 (58%)

919 (8%)

Trans

Multiple studies [2, 46]

1777

40 (2%)

0.0007 (0%)

Battle et al. [7]

2596

102 (4%)

0.0001 (0%)

Kirsten et al. [8]

2337

135 (6%)

0.03 (0%)

  1. aSee “Methods” and Additional file 1: Supplementary Methods for details
  2. P values (comparing Validated to Expected pairs are based on Poisson distribution) are all <1E-200