From: GAVIN: Gene-Aware Variant INterpretation for medical sequencing
Tool | Median sensitivity (%) | Median specificity (%) |
---|---|---|
CADD (thr. 15) | 93.6 | 57.1 |
CADD (thr. 20) | 90.4 | 68.8 |
CADD (thr. 25) | 71.5 | 85.3 |
Condel | 70.3 | 39.5 |
DANN | 63.8 | 66.7 |
FATHMM | 69.5 | 61.9 |
FunSeq | 61.7 | 50.2 |
GAVIN | 91.4 | 76.9 |
GWAVA | 47.6 | 26.2 |
MSC_ClinVar95CI | 84.7 | 64.4 |
MSC_HGMD99CI | 97.1 | 25.7 |
PolyPhen2 | 68.0 | 46.8 |
PONP2 | 47.5 | 26.9 |
PredictSNP2 | 66.8 | 70.6 |
PROVEAN | 65.9 | 62.1 |
SIFT | 67.9 | 57.9 |