Table 2 WGCNA module summary and functional enrichments

Pink (100)

SPI1

0.83

GO:0006952 defense response (P _adj = 6.17e-07)

Neutrophils (P = 7.46e-11)

PLEK

GO:0006955 immune response (P _adj = 2.25e-06)

Act. neutrophils (P = 4.44e-09)

HCK

IPA path: Fcγ receptor-mediated phagocytosis in macrophages and monocytes (P = 4.97e-10)

Eosinophils (P = 3.74e-04)

FGR

IPA upstream regulator: IFNG (P = 4.77e-16)

Act. macrophages (P = 9.78e-03)

TLR4

IPA function: leukocyte migration (increased) (P = 3.82e-22)

Act. eosinophils (P = 2.67e-02)

Blue (726)

SLAMF7

0.75

GO:0006955 immune response (P _adj = 5.31e-76)

Act. macrophages (P = 2.49e-16)

SP100

GO:0006952 defense response (P _adj = 2.15e-29)

Dendritic cells (P = 3.01e-11)

DTX3L

GO:0045321 leukocyte activation (P _adj = 3.79e-26)

Act. neutrophils (P = 3.78e-05)

GIMAP4

IPA upstream regulator: IFNG (P = 1.66e-100)

Neutrophils (P = 1.99e-04)

OAS3

IPA path: interferon signaling (P = 3.35e-22)

NK cells (P = 2.64e-02)

Black (117)

DCAKD

0.28

GO:0031982 ~ vesicle (P _adj = 1.38e-02)

Act. macrophages (P = 4.06e-03)

GNA13

GO:0012505 endomembrane system (P _adj = 2.10e-02)

PICALM

IPA upstream regulator: CHEK2 (P = 6.49e-05)

CREB1

IPA path: ephrin receptor signaling (P = 3.26e-04)

LARP4

IPA function: viral infection (increased) (P = 1.02e-04)

Magenta (85)

TNKS2

0.32

No significant DAVID enrichments

Act. macrophages (P = 4.57e-02)

VCPIP1

IPA path: oxidative phosphorylation (P = 8.05e-05)

MIER1

IPA path: mitochondrial dysfunction (P = 6.51e-04)

CD2AP

IPA path: NF-κB signaling (P = 6.14e-03)

ARAP2

Yellow (189)

CHST9

0.70

No significant DAVID enrichments

Act. neutrophils (P = 4.00e-04)

ITGA5

IPA function: inflammatory response (P = 2.09e-11)

Act. macrophages (P = 9.78e-03)

C8orf47

IPA function: quantity of leukocytes (P = 1.67e-10)

Neutrophils (P = 1.56e-02)

OXSR1

IPA function: differentiation of cells (P = 1.74e-10)

Act. eosinophils (P = 1.83e-02)

ITPRIPL2

Green (179)

RPL10A

−0.46

GO:0006414 translational elongation (P _adj = 3.65e-44)

B cells (P _adj = 1.07e-07)

RPL3

KEGG: hsa03010 ribosome (P _adj = 3.34e-37)

Th2 cells (P _adj = 8.30e-05)

EEF2

GO:0006412 translation (P _adj = 7.72e-36)

T cells (P _adj = 2.33e-04)

RPS14

IPA path: eIF2 signaling (P = 4.07e-47)

Mast cells (P _adj = 1.33e-03)

RPL4

Th1 cells (P _adj = 2.42e-02)

Brown (203)

ELOVL5

−0.74

Type 2 inflammation (P = 3.30e-04)

No significant immune cell enrichments

CDH26

No significant DAVID enrichments

ALOX15

IPA upstream regulator: IL13 (P = 2.77e-05)

FETUB

VWF

Red (164)

CFL1

0.50

GO:0015629 actin cytoskeleton (P _adj = 2.41e-06)

Act. neutrophils (P _adj = 2.35e-02)

CAP1

GO:0031252 cell leading edge (P _adj = 6.68e-05)

Act. macrophages (P _adj = 3.04e-02)

VASP

IPA path: remodeling of epithelial adherens junctions (P = 2.42e-09)

DIAPH1

IPA upstream predictor: TGFB1 (P = 6.88e-09)

TMBIM1

IPA function: organization of cytoskeleton (increased) (P = 3.65e-15)

Turquoise (1,615)

C6orf165

−0.43

GO:0005929 cilium (P _adj = 2.78e-30)

No significant immune cell enrichments

ARMC2

GO:0015630 microtubule cytoskeleton (P _adj = 1.02e-23)

CAPSL

GO:0005930 axoneme (P = 3.01e-21)

EFCAB6

IPA upstream regulator: RFX3 (P = 1.74e-05)

ANKRD66

IPA function: formation of cilia (decreased) (P = 1.47e-43)