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Fig. 4 | Genome Biology

Fig. 4

From: iRegNet3D: three-dimensional integrated regulatory network for the genomic analysis of coding and non-coding disease mutations

Fig. 4

Analysis of disease-associated non-coding mutations located at TF binding motifs. a Enrichment of HGMD non-coding mutations and population SNPs in TF binding motifs. *P < 0.05, **P < 10–2, ***P < 10–3. P values calculated using the Z-test on log enrichment. Error bars indicate ± SE. b Fraction of TF binding motif-localized non-coding mutation pairs causing the same disease. Error bars indicate ± SEM. *P < 0.05. P values calculated using the cumulative binomial test. n.s. not significant. c Fraction of TF binding motif-localized non-coding mutation pairs on the same chromosome causing the same disease. Error bars indicate ± SEM. *P < 0.05, ***P < 10–3. P values calculated using the cumulative binomial test. d Fraction of TF binding motif-localized non-coding mutation pairs in the same anchor causing the same disease. Error bars indicate ± SEM. **P < 10–2, ***P < 10–3. n.s. not significant. P values calculated using the cumulative binomial test. e Fraction of TF binding motif-localized non-coding mutation pairs across interacting regions causing the same disease. Error bars indicate ± SEM. ***P < 10–3. n.s. not significant. P values calculated using the cumulative binomial test. f Enrichment of motif pairs of interacting TFs across interacting chromatin regions. Error bars indicate ± SEM. ***P < 10–3. P values calculated using the Z-test on log enrichment

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