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Fig. 3 | Genome Biology

Fig. 3

From: iRegNet3D: three-dimensional integrated regulatory network for the genomic analysis of coding and non-coding disease mutations

Fig. 3

Analysis of disease-associated non-coding mutations and their locus heterogeneity. a Enrichment of HGMD non-coding mutations in different gene regulatory regions. *P < 0.05, **P < 10–2, ***P < 10–3. P values calculated using the Z-test on log enrichment. Error bars indicate ± SE. b Fraction of HGMD non-coding mutation pairs causing the same disease. Error bars indicate ± SEM. P values calculated using the cumulative binomial test. c Normalized number of chromosomal contacts for mutation pairs associated with the same disease or different diseases. ***P < 10–3. P values calculated using the Mann-Whitney U test. Light blue dots indicate the mean. Dark blue lines indicate the median

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