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Fig. 5 | Genome Biology

Fig. 5

From: Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution

Fig. 5

Manhattan plots meta-analyses across four cohorts of EWAS and TWAS of age and smoking status. Panel a shows the meta-analysis results of the EWAS of age as − log10P values and with reverse sign for the TWAS of age as log10P values. Panel b shows the same figure for smoking. The black line indicates 0.05 Bonferroni thresholds. Red gene names highlight the top 10 (nearest) genes resulting from the EWAS and TWAS. Black gene names denote genes that were identified in both the EWAS and TWAS (genes for EWAS are the genes closest to the significant CpG)

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Genome Biology

ISSN: 1474-760X

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