Table 2 DNA methylation sites associated with serum CRP levels
From: DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases
CpG sites | Chr | Position | Effect size EA | P value EA | Effect size AA | P value AA | Gene |
|---|---|---|---|---|---|---|---|
cg10636246 | 1 | 159046973 | −0.0069 | 2.53 × 10−27 | −0.0081 | 6.31 × 10−09 | AIM2 |
cg17501210 | 6 | 166970252 | −0.0065 | 2.06 × 10−26 | −0.0076 | 9.45 × 10−05 | RPS6KA2 |
cg02650017 | 17 | 47301614 | −0.0021 | 4.87 × 10−25 | −0.0011 | 7.71 × 10−06 | PHOSPHO1 |
cg12992827 | 3 | 101901234 | −0.0057 | 9.73 × 10−22 | −0.0086 | 4.42 × 10−14 | NFKBIZ |
cg16936953 | 17 | 57915665 | −0.0077 | 3.74 × 10−21 | −0.0125 | 1.13 × 10−13 | TMEM49 |
cg19821297 | 19 | 12890029 | −0.0051 | 5.19 × 10−21 | −0.0055 | 6.58 × 10−06 | GCDH |
cg07573872 | 19 | 1126342 | −0.0052 | 1.24 × 10−20 | −0.0068 | 2.98 × 10−09 | SBNO2 |
cg26470501 | 19 | 45252955 | −0.0045 | 2.85 × 10−20 | −0.0051 | 4.08 × 10−07 | BCL3 |
cg12054453 | 17 | 57915717 | −0.0082 | 6.96 × 10−20 | −0.0117 | 4.25 × 10−12 | TMEM49 |
cg18608055 | 19 | 1130866 | −0.0043 | 1.94 × 10−19 | −0.0078 | 2.96 × 10−11 | SBNO2 |
cg06192883 | 15 | 52554171 | 0.0045 | 2.29 × 10−19 | 0.0073 | 8.29 × 10−12 | MYO5C |
cg18181703 | 17 | 76354621 | −0.0053 | 2.13 × 10−18 | −0.0091 | 7.08 × 10−13 | SOCS3 |
cg18942579 | 17 | 57915773 | −0.0056 | 4.77 × 10−16 | −0.0098 | 8.70 × 10−12 | TMEM49 |
cg19769147 | 14 | 105860954 | 0.0029 | 1.51 × 10−15 | 0.0029 | 6.60 × 10−05 | PACS2 |
cg20995564 | 2 | 145172035 | −0.0051 | 2.04 × 10−15 | −0.0089 | 2.69 × 10−10 | ZEB2 |
cg02734358 | 4 | 90227074 | −0.0048 | 3.09 × 10−15 | −0.0051 | 5.51 × 10−05 | GPRIN3 |
cg07094298 | 4 | 2748026 | −0.0056 | 4.76 × 10−15 | −0.0058 | 5.32 × 10−06 | TNIP2 |
cg01059398 | 3 | 172235808 | −0.0042 | 4.51 × 10−14 | −0.0068 | 2.27 × 10−05 | TNFSF10 |
cg06690548 | 4 | 139162808 | −0.0048 | 1.21 × 10−13 | −0.0029 | 1.52 × 10−07 | SLC7A11 |
cg02003183 | 14 | 103415882 | 0.0047 | 3.59 × 10−13 | 0.0051 | 4.36 × 10−05 | CDC42BPB |
cg26804423 | 7 | 8201134 | 0.0027 | 3.87 × 10−13 | 0.0038 | 4.82 × 10−07 | ICA1 |
cg13585930 | 10 | 72027357 | −0.0037 | 1.42 × 10−12 | −0.0046 | 7.95 × 10−05 | NPFFR1 |
cg03957124 | 6 | 37016869 | −0.0030 | 3.13 × 10−12 | −0.0039 | 1.39 × 10−05 | FGD2 |
cg12053291 | 12 | 125282342 | 0.0029 | 5.99 × 10−12 | 0.0038 | 9.80 × 10−05 | SCARB1 |
cg02481950 | 16 | 21665002 | 0.0022 | 7.84 × 10−12 | 0.0034 | 2.92 × 10−06 | METTL9 |
cg04987734 | 14 | 103415873 | 0.0041 | 8.40 × 10−12 | 0.0051 | 1.40 × 10−04 | CDC42BPB |
cg15551881 | 9 | 123688715 | 0.0039 | 4.62 × 10−11 | 0.0049 | 3.99 × 10−07 | TRAF1 |
cg27023597 | 17 | 57918262 | −0.0050 | 5.02 × 10−11 | −0.0070 | 5.96 × 10−06 | MIR21 |
cg05575921 | 5 | 373378 | −0.0059 | 5.44 × 10−11 | −0.0063 | 1.17 × 10−04 | AHRR |
cg27469606 | 19 | 1154485 | −0.0020 | 5.62 × 10−11 | −0.0023 | 1.96 × 10−06 | SBNO2 |
cg01409343 | 17 | 57915740 | −0.0037 | 3.56 × 10−10 | −0.0081 | 6.12 × 10−10 | TMEM49 |
cg21429551 | 7 | 30635762 | −0.0069 | 4.42 × 10−10 | −0.0080 | 1.68 × 10−05 | GARS |
cg23761815 | 10 | 73083123 | 0.0022 | 8.86 × 10−10 | 0.0029 | 6.85 × 10−05 | SLC29A3 |
cg08548559 | 22 | 31686097 | −0.0038 | 9.94 × 10−10 | −0.0049 | 9.88 × 10−05 | PIK3IP1 |
cg26610247 | 8 | 142297175 | 0.0029 | 1.07 × 10−09 | 0.0041 | 4.59 × 10−06 | TSNARE1 |
cg27050612 | 17 | 46133198 | −0.0019 | 1.30 × 10−09 | −0.0029 | 8.23 × 10−05 | NFE2L1 |
cg15721584 | 3 | 181326755 | 0.0055 | 1.71 × 10−09 | 0.0072 | 1.14 × 10−05 | SOX2OT |
cg06126421 | 6 | 30720080 | −0.0052 | 1.80 × 10−09 | −0.0059 | 1.53 × 10−04 | TUBB |
cg00851028 | 1 | 234905772 | 0.0023 | 1.95 × 10−09 | 0.0042 | 1.46 × 10−05 | - |
cg24174557 | 17 | 57903544 | −0.0038 | 1.97 × 10−09 | −0.0051 | 1.65 × 10−04 | TMEM49 |
cg05316065 | 8 | 130799007 | −0.0027 | 2.26 × 10−09 | −0.0051 | 2.28 × 10−07 | GSDMC |
cg04523589 | 3 | 48265146 | 0.0022 | 2.49 × 10−09 | 0.0031 | 4.47 × 10−05 | CAMP |
cg17980786 | 3 | 32933637 | 0.0026 | 4.58 × 10−09 | 0.0055 | 1.47 × 10−09 | TRIM71 |
cg25325512 | 6 | 37142220 | −0.0031 | 5.31 × 10−09 | −0.0052 | 4.94 × 10−05 | PIM1 |
cg00812761 | 4 | 53799391 | 0.0025 | 5.60 × 10−09 | 0.0036 | 1.36 × 10−04 | SCFD2 |
cg27637521 | 17 | 76355202 | −0.0016 | 5.69 × 10−09 | −0.0017 | 3.69 × 10−05 | SOCS3 |
cg26846781 | 17 | 61620942 | 0.0018 | 5.99 × 10−09 | 0.0033 | 3.03 × 10−05 | KCNH6 |
cg00159243 | 12 | 109023799 | −0.0026 | 8.22 × 10−09 | −0.0036 | 1.38 × 10−04 | SELPLG |
cg15310871 | 8 | 20077936 | 0.0022 | 8.63 × 10−09 | 0.0027 | 2.96 × 10−05 | ATP6V1B2 |
cg15020801 | 17 | 46022809 | 0.0024 | 1.67 × 10−08 | 0.0033 | 9.47 × 10−05 | PNPO |
cg03128029 | 2 | 203143288 | −0.0027 | 1.90 × 10−08 | −0.0036 | 2.03 × 10−04 | NOP58 |
cg22749855 | 17 | 76353952 | −0.0024 | 3.22 × 10−08 | −0.0035 | 5.15 × 10−05 | SOCS3 |
cg02341197 | 21 | 34185927 | 0.0030 | 3.92 × 10−08 | 0.0045 | 2.54 × 10−05 | C21orf62 |
cg12269535 | 6 | 43142014 | −0.0028 | 4.39 × 10−08 | −0.0046 | 1.57 × 10−04 | SRF |
cg25392060 | 8 | 142297121 | 0.0025 | 5.60 × 10−08 | 0.0036 | 2.15 × 10−04 | TSNARE1 |
cg27184903 | 15 | 29285727 | 0.0024 | 5.84 × 10−08 | 0.0052 | 4.91 × 10−07 | APBA2 |
cg18663307 | 21 | 46341389 | 0.0029 | 6.98 × 10−08 | 0.0048 | 1.04 × 10−04 | ITGB2 |
cg09182678 | 22 | 50328711 | −0.0016 | 9.02 × 10−08 | −0.0019 | 1.26 × 10−04 | DENND6B |