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Table 2 DNA methylation sites associated with serum CRP levels

From: DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

CpG sites Chr Position Effect size EA P value EA Effect size AA P value AA Gene
cg10636246 1 159046973 −0.0069 2.53 × 10−27 −0.0081 6.31 × 10−09 AIM2
cg17501210 6 166970252 −0.0065 2.06 × 10−26 −0.0076 9.45 × 10−05 RPS6KA2
cg02650017 17 47301614 −0.0021 4.87 × 10−25 −0.0011 7.71 × 10−06 PHOSPHO1
cg12992827 3 101901234 −0.0057 9.73 × 10−22 −0.0086 4.42 × 10−14 NFKBIZ
cg16936953 17 57915665 −0.0077 3.74 × 10−21 −0.0125 1.13 × 10−13 TMEM49
cg19821297 19 12890029 −0.0051 5.19 × 10−21 −0.0055 6.58 × 10−06 GCDH
cg07573872 19 1126342 −0.0052 1.24 × 10−20 −0.0068 2.98 × 10−09 SBNO2
cg26470501 19 45252955 −0.0045 2.85 × 10−20 −0.0051 4.08 × 10−07 BCL3
cg12054453 17 57915717 −0.0082 6.96 × 10−20 −0.0117 4.25 × 10−12 TMEM49
cg18608055 19 1130866 −0.0043 1.94 × 10−19 −0.0078 2.96 × 10−11 SBNO2
cg06192883 15 52554171 0.0045 2.29 × 10−19 0.0073 8.29 × 10−12 MYO5C
cg18181703 17 76354621 −0.0053 2.13 × 10−18 −0.0091 7.08 × 10−13 SOCS3
cg18942579 17 57915773 −0.0056 4.77 × 10−16 −0.0098 8.70 × 10−12 TMEM49
cg19769147 14 105860954 0.0029 1.51 × 10−15 0.0029 6.60 × 10−05 PACS2
cg20995564 2 145172035 −0.0051 2.04 × 10−15 −0.0089 2.69 × 10−10 ZEB2
cg02734358 4 90227074 −0.0048 3.09 × 10−15 −0.0051 5.51 × 10−05 GPRIN3
cg07094298 4 2748026 −0.0056 4.76 × 10−15 −0.0058 5.32 × 10−06 TNIP2
cg01059398 3 172235808 −0.0042 4.51 × 10−14 −0.0068 2.27 × 10−05 TNFSF10
cg06690548 4 139162808 −0.0048 1.21 × 10−13 −0.0029 1.52 × 10−07 SLC7A11
cg02003183 14 103415882 0.0047 3.59 × 10−13 0.0051 4.36 × 10−05 CDC42BPB
cg26804423 7 8201134 0.0027 3.87 × 10−13 0.0038 4.82 × 10−07 ICA1
cg13585930 10 72027357 −0.0037 1.42 × 10−12 −0.0046 7.95 × 10−05 NPFFR1
cg03957124 6 37016869 −0.0030 3.13 × 10−12 −0.0039 1.39 × 10−05 FGD2
cg12053291 12 125282342 0.0029 5.99 × 10−12 0.0038 9.80 × 10−05 SCARB1
cg02481950 16 21665002 0.0022 7.84 × 10−12 0.0034 2.92 × 10−06 METTL9
cg04987734 14 103415873 0.0041 8.40 × 10−12 0.0051 1.40 × 10−04 CDC42BPB
cg15551881 9 123688715 0.0039 4.62 × 10−11 0.0049 3.99 × 10−07 TRAF1
cg27023597 17 57918262 −0.0050 5.02 × 10−11 −0.0070 5.96 × 10−06 MIR21
cg05575921 5 373378 −0.0059 5.44 × 10−11 −0.0063 1.17 × 10−04 AHRR
cg27469606 19 1154485 −0.0020 5.62 × 10−11 −0.0023 1.96 × 10−06 SBNO2
cg01409343 17 57915740 −0.0037 3.56 × 10−10 −0.0081 6.12 × 10−10 TMEM49
cg21429551 7 30635762 −0.0069 4.42 × 10−10 −0.0080 1.68 × 10−05 GARS
cg23761815 10 73083123 0.0022 8.86 × 10−10 0.0029 6.85 × 10−05 SLC29A3
cg08548559 22 31686097 −0.0038 9.94 × 10−10 −0.0049 9.88 × 10−05 PIK3IP1
cg26610247 8 142297175 0.0029 1.07 × 10−09 0.0041 4.59 × 10−06 TSNARE1
cg27050612 17 46133198 −0.0019 1.30 × 10−09 −0.0029 8.23 × 10−05 NFE2L1
cg15721584 3 181326755 0.0055 1.71 × 10−09 0.0072 1.14 × 10−05 SOX2OT
cg06126421 6 30720080 −0.0052 1.80 × 10−09 −0.0059 1.53 × 10−04 TUBB
cg00851028 1 234905772 0.0023 1.95 × 10−09 0.0042 1.46 × 10−05 -
cg24174557 17 57903544 −0.0038 1.97 × 10−09 −0.0051 1.65 × 10−04 TMEM49
cg05316065 8 130799007 −0.0027 2.26 × 10−09 −0.0051 2.28 × 10−07 GSDMC
cg04523589 3 48265146 0.0022 2.49 × 10−09 0.0031 4.47 × 10−05 CAMP
cg17980786 3 32933637 0.0026 4.58 × 10−09 0.0055 1.47 × 10−09 TRIM71
cg25325512 6 37142220 −0.0031 5.31 × 10−09 −0.0052 4.94 × 10−05 PIM1
cg00812761 4 53799391 0.0025 5.60 × 10−09 0.0036 1.36 × 10−04 SCFD2
cg27637521 17 76355202 −0.0016 5.69 × 10−09 −0.0017 3.69 × 10−05 SOCS3
cg26846781 17 61620942 0.0018 5.99 × 10−09 0.0033 3.03 × 10−05 KCNH6
cg00159243 12 109023799 −0.0026 8.22 × 10−09 −0.0036 1.38 × 10−04 SELPLG
cg15310871 8 20077936 0.0022 8.63 × 10−09 0.0027 2.96 × 10−05 ATP6V1B2
cg15020801 17 46022809 0.0024 1.67 × 10−08 0.0033 9.47 × 10−05 PNPO
cg03128029 2 203143288 −0.0027 1.90 × 10−08 −0.0036 2.03 × 10−04 NOP58
cg22749855 17 76353952 −0.0024 3.22 × 10−08 −0.0035 5.15 × 10−05 SOCS3
cg02341197 21 34185927 0.0030 3.92 × 10−08 0.0045 2.54 × 10−05 C21orf62
cg12269535 6 43142014 −0.0028 4.39 × 10−08 −0.0046 1.57 × 10−04 SRF
cg25392060 8 142297121 0.0025 5.60 × 10−08 0.0036 2.15 × 10−04 TSNARE1
cg27184903 15 29285727 0.0024 5.84 × 10−08 0.0052 4.91 × 10−07 APBA2
cg18663307 21 46341389 0.0029 6.98 × 10−08 0.0048 1.04 × 10−04 ITGB2
cg09182678 22 50328711 −0.0016 9.02 × 10−08 −0.0019 1.26 × 10−04 DENND6B
  1. Effect sizes represent the changes in normalized DNA methylation Beta-values per 1-unit increase in natural log-transformed CRP (mg/L)
  2. Chr and Position are in GRCh37/hg19
  3. AA African American, EA European Ancestry