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Table 1 Characteristics of the discovery (n = 8863) and replication (n = 4111) studies

From: DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

Study n Country Age (years) Women (%) CRP (mg/L) BMI (kg/m2)
Discovery (European)
 CHS 187 USA 76 (5) 56 6.6 (11.0) 31 (6)
 EPIC-Norfolk 1287 UK 60 (9) 54 3.3 (5.4) 27 (4)
 FHS 2427 USA 66 (9) 52 3.1 (6.7) 28 (5)
 InCHIANTI 498 Italy 63 (16) 55 3.2 (3.5) 27 (4)
 KORA 1700 Germany 61 (9) 51 2.3 (3.7) 28 (5)
 LBC 1921 169 UK 87 (0) 54 3.7 (8.4) 26 (4)
 LBC 1936 296 UK 70 (1) 50 5.3 (6.8) 28 (4)
 NAS 648 USA 73 (7) 0 3.3 (6.1) 28 (4)
 Rotterdam 702 Netherlands 60 (8) 54 2.7 (4.7) 28 (5)
 WHI controls 471 USA 68 (6) 100 3.8 (5.5) 28 (6)
 WHI cases 478 USA 69 (6) 100 4.9 (6.4) 29 (6)
Replication (African American)
 ARIC 2264 USA 56 (6) 64 5.9 (7.8) 30 (6)
 CHS 193 USA 73 (5) 65 5.2 (5.6) 29 (5)
 GENOA 939 USA 66 (8) 71 6.7 (12.3) 31 (6)
 GTP 112 USA 41 (13) 70 5.9 (8.1) 33 (8)
 WHI controls 309 USA 62 (6) 100 6.1 (7.5) 31 (7)
 WHI cases 294 USA 64 (7) 100 7.2 (8.4) 32 (6)
  1. Characteristics are mean (SD), unless otherwise specified
  2. ARIC Atherosclerosis Risk in Communities, BMI body mass index, CHS Cardiovascular Health Study, CRP C-reactive protein, EPIC-Norfolk European Prospective Investigation into Cancer and Nutrition Norfolk, FHS Framingham Heart Study, GENOA Genetic Epidemiology Network of Arteriopathy, InCHIANTI Invecchiare in Chianti, KORA Kooperative Gesundheitsforschung in der Region Augsburg, LBC Lothian Birth Cohort, NAS Normative Aging Study, UK United Kingdom, USA United States of America, WHI Women’s Health Initiative