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Fig. 4 | Genome Biology

Fig. 4

From: Human splicing diversity and the extent of unannotated splice junctions across human RNA-seq samples on the Sequence Read Archive

Fig. 4

Displayed is the first principal component (PC1) vs. the second principal component (PC2) for a principal component analysis (PCA) with a coverage data matrix where rows are junctions and columns are samples. (See Methods for technical details.) Each point corresponds to a distinct sample. Gray points are unlabeled samples, red points are blood samples, magenta points are lymphoblastoid cell line samples, and cyan points are brain samples. GEUVADIS (GEU) is a sizable cluster of magenta points. The ABRF and SEQC consortia each sequenced mixtures of universal human reference RNA (UHRR) and human brain reference RNA (HBRR) in four sample ratios UHRR:HBRR that form distinct clusters in the shaded regions: 0:1 (green), 1:3 (blue), 3:1 (brown), and 1:0 (yellow)

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