TY - JOUR AU - Demeulemeester, Jonas AU - Kumar, Parveen AU - Møller, Elen K. AU - Nord, Silje AU - Wedge, David C. AU - Peterson, April AU - Mathiesen, Randi R. AU - Fjelldal, Renathe AU - Zamani Esteki, Masoud AU - Theunis, Koen AU - Fernandez Gallardo, Elia AU - Grundstad, A. Jason AU - Borgen, Elin AU - Baumbusch, Lars O. AU - Børresen-Dale, Anne-Lise AU - White, Kevin P. AU - Kristensen, Vessela N. AU - Van Loo, Peter AU - Voet, Thierry AU - Naume, Bjørn PY - 2016 DA - 2016/12/09 TI - Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing JO - Genome Biology SP - 250 VL - 17 IS - 1 AB - Single-cell micro-metastases of solid tumors often occur in the bone marrow. These disseminated tumor cells (DTCs) may resist therapy and lay dormant or progress to cause overt bone and visceral metastases. The molecular nature of DTCs remains elusive, as well as when and from where in the tumor they originate. Here, we apply single-cell sequencing to identify and trace the origin of DTCs in breast cancer. SN - 1474-760X UR - https://doi.org/10.1186/s13059-016-1109-7 DO - 10.1186/s13059-016-1109-7 ID - Demeulemeester2016 ER -