Table 4 Conditional analysis of selected regions adjusting for the lead common variant identified by previous genome-wide association studies
From: Whole genome sequence analysis of serum amino acid levels
Metabolite | Region | Type | GWAS Lead SNV | Discovery (AA) | Replication (EA) | ||
|---|---|---|---|---|---|---|---|
P unadjusted | P adjusted | P unadjusted | P adjusted | ||||
Indolelactate* | CCBL1 | Gene | rs15676 | 1.3 × 10−20 | 1.1 × 10−20 | 2.1 × 10−6 | 4.1 × 10−6 |
N-acetyl-1-methylhistidine | Chr2: 73744005–73748004 (NAT8) | Window | rs13538 | 1.6 × 10−15 | 0.005 | 4.0 × 10−4 | 0.2 |
N-acetyl-1-methylhistidine | Chr2: 73614005–73618004 (NAT8) | Window | rs13538 | 6.2 × 10−11 | 0.9 | 0.005 | 0.8 |
Asparagine* | AGA | Gene | rs4690522 | 6.8 × 10−10 | 9.1 × 10−10 | 1.5 × 10−5 | 6.0 × 10−8 |
Dimethlyglycine* | DMGDH | Gene | rs248386 | 1.1 × 10−26 | 4.3 × 10−27 | 4.4 × 10−11 | 4.5 × 10−10 |
Alpha-hydroxyisovalerate* | HAO2 | Gene | rs12141041 | 1.5 × 10−5 | 3.0 × 10−5 | 9.3 × 10−5 | 2.0 × 10−4 |
Proline* | PRODH | Gene | rs2540641 | 1.4 × 10−26 | 1.7 × 10−26 | 1.3 × 10−12 | 1.2 × 10−13 |