Fig. 1

Evaluation of RP expression specificity across human tissues, primary cells, and tumors. The expression levels of RP genes across human tissues and primary cells were obtained from the FANTOM5 project repository. Gene expression data for matched normal and tumor samples were retrieved from The Cancer Genome Atlas (TCGA). As the correlation of RP expression levels across samples was very high, tissue/cell-specific expression of individual RP genes was estimated relative to the average across samples. Similarly, the scores for RP dysregulation in tumors were computed relative to the linear fit to the RP expression in the matched normal tissue. Cap analysis gene expression (CAGE) is based on the purification and sequencing of the 5′ end of mRNAs