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Fig. 8 | Genome Biology

Fig. 8

From: Functional and regulatory profiling of energy metabolism in fission yeast

Fig. 8

Changes in carbon flow and ETC activity in three biological conditions investigated in this study. Cells grown on glucose gain energy mainly by fermentation (middle), but our data indicate that the ETC is also active in this situation and energy gained in respiration process contributes to final biomass production in YES media (Fig. 7a). Cells grown on glycerol gain energy mainly by respiration (right), reflected in the up-regulation of ETC transcripts presumably resulting in higher ETC activity. Signals from mitochondrial damage results in repression of the ETC components, except for complex 2, which is also a part of the TCA cycle required for the synthesis of essential biomolecules. In this situation, cells gain all their energy through fermentation, which results in lower biomass production (Fig. 7a)

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