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Fig. 3 | Genome Biology

Fig. 3

From: Systematic analysis of chromatin interactions at disease associated loci links novel candidate genes to inflammatory bowel disease

Fig. 3

GSEA for candidate genes in intestinal inflammation in IBD. The figure shows the GSEA for the candidate genes reported in monocytes, lymphocytes, and DLDs. Genes that are upregulated (red) in inflamed compared to non-inflamed biopsies are plotted to the left of the x-axes, downregulated genes (blue) on the right. 4C-seq gene sets are significantly (p < 0.001) enriched for genes that are upregulated in the inflamed intestine of IBD patients (reflected by positive normalized enrichment score, NES). Enrichment score (ES) reflects the degree to which the 4C-seq genes sets are over-represented at the differentially expressed genes in intestinal biopsies. The nominal p value and the normalized enrichment score (NES, normalized for the size of the gene sets) are shown below each graph

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