Skip to main content
Fig. 5 | Genome Biology

Fig. 5

From: Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans

Fig. 5

The Neandertal haplotype in the OAS regions has a different impact on the regulation of OAS genes depending on the viral agents PBMCs are exposed to. a Log 2 fold induction (y-axis) of OAS1, OAS2, and OAS3 in response to different viral agents or viral-associated immune stimuli, relative to non-infected PBMCs. b –log10 P for the association between genotype status for the Neandertal haplotype and overall expression levels of OAS genes and the expression of specific isoforms of OAS1 and OAS2 (those identified in Fig. 3 as associated with NLS). Boxplots show the association between genotype status (blue referring to Neanderthal alleles) and expression levels of the p46 isoform of OAS1 and OAS3 in Gardiquimod-stimulated PBMCs

Back to article page