Fig. 6

Prognostic significance of ccRCC immune infiltration classes and distinct T cell subsets. a Kaplan–Meier curves for cancer-specific survival in ccRCC immune infiltration classes. The T cell enriched class has the poorest survival whereas the non-infiltrated class is associated with better outcomes (log-rank test p value = 0.05). b Prognostic significance of angiogenesis and distinct T cell subsets in ccRCC. Univariate Cox proportional-hazards was used to regress ssGSEA scores on cancer-specific survival. The resultant p values in the TCGA dataset were adjusted for multiple hypothesis testing, log-transformed, and then plotted against the log-transformed p values from the SATO dataset. Survival associations concordant in both datasets are denoted in green and red for improved and poor outcome respectively. Discordant associations are denoted in gray. P values from the SATO dataset are not adjusted for multiple hypothesis testing since this is the validation cohort. c Kaplan–Meier curves for cancer-specific survival in the above-median and below-median groups for the CD8⁺ T/Treg and Th17/Th2 ratios. The median values for these two ratios are able to stratify both the TCGA and the SATO cohorts into groups with significant survival differences