Fig. 3

Analysis of T cell infiltration in 19 tumor types. a T cell infiltration scores (TIS) and the corresponding mutation load in 19 tumor types. TIS is an aggregate score obtained as the average of nine distinct T cell subset scores (CD8⁺ T, Th1, Th2, Th17, Treg, T effector memory, T central memory, T helper, and T cells). Each circle in the top panel shows the TIS for a tumor sample. In the bottom panel, the vertical bar corresponding to each circle shows the number of somatic missense mutations. Tumor types are ordered from left to right according to increasing median TIS (medians indicated by horizontal gray bars). b Correlation of mutation load with TIS and levels of individual T cell subpopulations. Spearman correlation coefficients are computed between number of somatic missense mutations and ssGSEA-based immune cell infiltration levels. Coefficients are plotted on the y-axis in bar plots and asterisks are added to indicate level of significance, as denoted in the legend. Tumor types are ordered in the same order as in Fig. 3a