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Table 3 KEGG pathways significantly shared among ASD and its co-morbidities a

From: Integrative analysis of genetic data sets reveals a shared innate immune component in autism spectrum disorder and its co-morbidities

Pathway ASD Asthma Bacterial Chronic Cerebral Dilated Ear Epilepsy Inflammatory Muscular Schizo Upper Chi- p value from Bonferroni
    and viral kidney palsy cardio infection   bowel dystrophy phrenia respiratory square chi-square corrected
    infection disease   myopathy    disease    infection value distribution p value
Toll-like receptor 0.0048* 5.52E-06* 0.0762 0.0114* 0.6550 0.0034* 4.28E-16* 1 5.93E-05* 0.0210* 1 1.14E-10* 189.1151 1.1745E-32* 1.703E-30*
signaling pathway                
Chemokine signaling 0.0145* 0.0003* 0.000051* 0.2197 0.8628 0.0194* 3.21E-10* 1 1.37E-06* 0.5703 1 8.89E-09* 170.8496 7.0449E-26* 1.022E-21*
pathway                
NOD-like receptor 0.0342* 9.02E-05* 0.0136* 0.0019* 0.4760 0.0019* 1.99E-08* 1 0.0036* 0.7335 1 9.04E-05* 116.9434 1.7813E-17* 2.583E-15*
signaling pathway                
Ribosome 6.49E-13* 0.9647 4.84E-10* 0.1720 0.6006 1 0.984089 1 0.9460 0.0026* 1 1 119.0004 3.68E-17* 5.336E-15*
Spliceosome 6.70E-05* 0.9541 6.39E-06* 0.2965 0.3831 0.2746 0.920135 1 1.36E-05* 0.5081 0.1721 1 82.5337 9.9149E-09* 1.438E-06*
Leukocyte trans- 0.0023* 0.8201 0.0110* 0.0797 0.0002* 0.8164 0.097372 1 0.1238 7.63E-06* 0.5000 1 75.6280 9.962E-09* 1.445E-06*
endothelial migration                
Regulation of actin 0.0234* 0.9080 0.2734 0.1131 0.0745 0.0355* 0.227981 1 0.2032 5.90E-05* 0.1330 1 73.9701 2.7324E-05* 0.003962*
cyto-skeleton                
Tight junction 0.0359* 0.5613 0.4111 0.1064 0.0005* 0.8542 0.303934 1 0.1900 0.0006* 1 1 56.2763 6.9114E-05* 0.010022*
  1. ASD autism spectrum disorder, KEGG Kyoto Encyclopedia of Genes and Genomes
  2. aThe entries with value ‘1’ indicate where there was no overlap between the pathway and the disease gene set
  3. *Entries with significant p values