Skip to main content

Table 3 KEGG pathways significantly shared among ASD and its co-morbidities a

From: Integrative analysis of genetic data sets reveals a shared innate immune component in autism spectrum disorder and its co-morbidities

Pathway

ASD

Asthma

Bacterial

Chronic

Cerebral

Dilated

Ear

Epilepsy

Inflammatory

Muscular

Schizo

Upper

Chi-

p value from

Bonferroni

   

and viral

kidney

palsy

cardio

infection

 

bowel

dystrophy

phrenia

respiratory

square

chi-square

corrected

   

infection

disease

 

myopathy

  

disease

  

infection

value

distribution

p value

Toll-like receptor

0.0048*

5.52E-06*

0.0762

0.0114*

0.6550

0.0034*

4.28E-16*

1

5.93E-05*

0.0210*

1

1.14E-10*

189.1151

1.1745E-32*

1.703E-30*

signaling pathway

               

Chemokine signaling

0.0145*

0.0003*

0.000051*

0.2197

0.8628

0.0194*

3.21E-10*

1

1.37E-06*

0.5703

1

8.89E-09*

170.8496

7.0449E-26*

1.022E-21*

pathway

               

NOD-like receptor

0.0342*

9.02E-05*

0.0136*

0.0019*

0.4760

0.0019*

1.99E-08*

1

0.0036*

0.7335

1

9.04E-05*

116.9434

1.7813E-17*

2.583E-15*

signaling pathway

               

Ribosome

6.49E-13*

0.9647

4.84E-10*

0.1720

0.6006

1

0.984089

1

0.9460

0.0026*

1

1

119.0004

3.68E-17*

5.336E-15*

Spliceosome

6.70E-05*

0.9541

6.39E-06*

0.2965

0.3831

0.2746

0.920135

1

1.36E-05*

0.5081

0.1721

1

82.5337

9.9149E-09*

1.438E-06*

Leukocyte trans-

0.0023*

0.8201

0.0110*

0.0797

0.0002*

0.8164

0.097372

1

0.1238

7.63E-06*

0.5000

1

75.6280

9.962E-09*

1.445E-06*

endothelial migration

               

Regulation of actin

0.0234*

0.9080

0.2734

0.1131

0.0745

0.0355*

0.227981

1

0.2032

5.90E-05*

0.1330

1

73.9701

2.7324E-05*

0.003962*

cyto-skeleton

               

Tight junction

0.0359*

0.5613

0.4111

0.1064

0.0005*

0.8542

0.303934

1

0.1900

0.0006*

1

1

56.2763

6.9114E-05*

0.010022*

  1. ASD autism spectrum disorder, KEGG Kyoto Encyclopedia of Genes and Genomes
  2. aThe entries with value ‘1’ indicate where there was no overlap between the pathway and the disease gene set
  3. *Entries with significant p values