Fig. 3

a Toll-like receptor signaling pathway color-tagged by co-morbidity findings. b Chemokine signaling pathway color-tagged by co-morbidity findings. Genes were mapped onto corresponding KEGG pathway using the “user data mapping tool” from KEGG [91, 92]. Genes are represented by rectangular boxeson KEGG pathways. We put color tags on a gene to indicate in which diseases it is differentially expressed. Sometimes a set of genes are mapped onto a single box. In that case, the color tags on that box represent the union set of all diseases in which those genes are differentially expressed. ASD autism spectrum disorder, CKD chronic kidney disease, CP cerebral palsy, DC dilated cardiomyopathy, EI ear infection, IBD inflammatory bowel disease, Infection bacterial and viral infection, KEGG Kyoto Encyclopedia of Genes and Genomes, MD muscular dystrophy, URI upper respiratory infection