Fig. 5
A high rate of RNA-editing sites are detected in mTEC cells (C to U). a C-to-U editing in ApoB gene in mTECs. Reads coverage in the ApoB C-to-U editing site (chr12:8014835–8014884), blue denotes the same nucleotide in the genome and in the mapped reads, brown denotes a T nucleotide in the reads instead of a C in the genome. b C-to-U editing levels in mTECs is comparable to the levels in colon. Heatmap of RNA-editing frequency in 77 sites originally found in the liver and colon edited in at least one of the examined cell types or tissues. Blue rectangle denotes editing site supported by ten reads or more (edited and non-edited reads), red rectangle denotes editing site supported by less than ten reads, white rectangle denotes no edited read was found, black rectangle denotes no reads were mapped to this editing site. c High levels of Apobec1 expression in mature mTECs correlate with high C-to-U editing levels. Correlation of Apobec1 expression levels (DEseq normalized reads count [71]) and editing levels (the number of edited reads detected in all 77 sites examined out of all reads detected in these sites). AireKO, mTEChi, and colon sample values are specified in the plot