Fig. 4

Higher rate of RNA-editing sites were detected in mTEC cells (A to I). a Heatmap of RNA-editing frequency in known non-synonymous RNA-editing sites (A to I) edited in at least one of the examined cell types or tissues. Blue rectangle denotes editing site supported by ten reads or more (edited and non-edited reads), red rectangle denotes editing site supported by less than ten reads, white rectangle denotes no edited reads were found, black rectangle denotes no reads were found in this editing site. The highest editing level in these non-synonymous sites was found in the brain. Mature mTECs and AireKO samples have relatively similar editing levels in these sites. b The number of hyper-editing sites in mTECs is comparable to the brain. The number of unique hyper-editing sites (A to I) per million aligned reads detected in each sample. c Global RNA-editing rate in mature mTECs is second to the brain and very similar to cTECs. The ratio of edited sites out of all editable sites expressed in each sample is represented