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Fig. 3 | Genome Biology

Fig. 3

From: Extensive RNA editing and splicing increase immune self-representation diversity in medullary thymic epithelial cells

Fig. 3

High level of AS in mTECs compared to other tissues. a Mature mTECs express the highest rate of alternatively spliced genes. A fraction of alternatively spliced genes detected in each tissue in four levels of gene expression (by quartiles). b Mature mTECs express a higher number of splice junctions per gene compare to other tissues. Dot plot of splice junctions number detected for each gene expressed in both mature mTECs (mTEChi) and each sample examined. Red dots denote a difference of more than five splice junctions per gene, gray dots denote five and fewer splice junctions difference per gene. Axes were limited between 0–100 splice junctions per gene. c Fyn alternative splicing pattern in mTECs, brain and spleen. Reads coverage of mutually exclusive exons in each tissue is presented. d Similar rate of tissue restricted spliced junctions is expressed in mature mTECs and AireKO samples. Fraction of tissue restricted spliced junctions (TRA junctions) expressed in mature mTECs and AireKO sample. Asterisk denotes a statistically significant change between mTEChi and AireKO sample (p value ≤ 0.05)

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