Fig. 2
mTEC cells express higher percentage of tissue specific genes compare to any other tissue. a Percentage of the tissue restricted antigens (TRA) genes of each tissue expressed in mature mTECs (mTEChi) and Aire-deficient (AireKO) cells. The number of TRA genes expressed in the tissue is indicated in parentheses. A relatively low fraction of TRA genes of testes and brain are expressed in mTECs. b Leave-one-out analysis comparing TRA expression across all tissues. The percentage of the coding genes uniquely expressed in both tissue 1 and tissue 2 (and not in other tissue examined) out of the genes expressed only in tissue 1 (and not in other tissue except tissue 2) are presented. The ratio of expressed TRA is the highest in mTECs compare to other tissues. cTEC cortical thymic epithelial cells, skinEC skin epithelial cells, skm skeletal muscle