Fig. 1

Long-range interactions in the 6q23 locus. Genomic co-ordinates are shown along the top of each panel and tracks are labelled a–n. a HindIII restriction fragments. b–e Regions targeted and restriction fragments included in the Region (b, c) and Promoter (d, e) Capture experiments. f GENCODE V17 genes. g–i 1000 Genomes SNPs in LD (r2 ≥ 0.8) with the index SNPs rs6920220, associated with RA, SLE, celiac disease, T1D and IBD (g), rs7752903, associated with RA, SLE and celiac disease (h) and rs610604, associated with Ps and PsA (i). j Topologically associated domains (TADs) in GM12878 cells [20]. k–n Significant interactions identified in the Region and Promoter capture experiments in GM12878 (k, l) and Jurkat (m, n) cells. The black arrow indicates the position of the rs6927172 SNP