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Fig. 3 | Genome Biology

Fig. 3

From: Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling

Fig. 3

Comparison of methylation values on the HM450 and EPIC platforms. a, b Density plots of the methylation (beta) values for a subset of samples profiled on both the HM450 and EPIC platforms, showing (a) all CpG probes on the HM450 (n = 482,421) and EPIC (n = 863,904) and (b) only CpG probes that are common to HM450 and EPIC platforms (n = 450,161). c Density plot of methylation values for the same subset of samples on the EPIC platform, showing shift in methylation values between Type I and II probes. df Scatter plots show correlation between methylation measurements from different platforms: EPIC-EPIC, EPIC-HM450 and EPIC-WGBS for (d) LNCaP and (e) PrEC; and EPIC-HM450 for (f) CAF, NAF and Guthrie samples

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