Prediction of gestational age based on genome-wide differentially methylated regions

Table 3 GA prediction results

	R²	SE	Number of CpGs
Ultrasound (Bonferroni adjusted)	0.65	12.7	105
LMP (Bonferroni adjusted)	0.52	14.6	84
Ultrasound (FDR adjusted)	0.67	12.4	132
LMP (FDR adjusted)	0.53	14.5	107
Ultrasound (MoBa 1)	0.66	12.5	96
LMP (MoBa 1)	0.5	14.9	58

Boferroni/FDR refers to Lasso models trained with CpGs from the regression model adjusted for a set of covariates, including cell-type, as well as multiple testing. MoBa 1 models were trained using the complete MoBa 1 methylation data. The R² column shows the goodness-of-fit statistics, based on MM-type robust regression, followed by standard error (SE) in ± days (95 % prediction interval) and the rightmost column designates the number of CpGs retained in each model

ISSN: 1474-760X