TY - JOUR AU - Slieker, Roderick C. AU - van Iterson, Maarten AU - Luijk, René AU - Beekman, Marian AU - Zhernakova, Daria V. AU - Moed, Matthijs H. AU - Mei, Hailiang AU - van Galen, Michiel AU - Deelen, Patrick AU - Bonder, Marc Jan AU - Zhernakova, Alexandra AU - Uitterlinden, André G. AU - Tigchelaar, Ettje F. AU - Stehouwer, Coen D. A. AU - Schalkwijk, Casper G. AU - van der Kallen, Carla J. H. AU - Hofman, Albert AU - van Heemst, Diana AU - de Geus, Eco J. AU - van Dongen, Jenny AU - Deelen, Joris AU - van den Berg, Leonard H. AU - van Meurs, Joyce AU - Jansen, Rick AU - ‘t Hoen, Peter A. C. AU - Franke, Lude AU - Wijmenga, Cisca AU - Veldink, Jan H. AU - Swertz, Morris A. AU - van Greevenbroek, Marleen M. J. AU - van Duijn, Cornelia M. AU - Boomsma, Dorret I. AU - Slagboom, P. Eline AU - Heijmans, Bastiaan T. AU - BIOS consortium PY - 2016 DA - 2016/09/22 TI - Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms JO - Genome Biology SP - 191 VL - 17 IS - 1 AB - Epigenetic change is a hallmark of ageing but its link to ageing mechanisms in humans remains poorly understood. While DNA methylation at many CpG sites closely tracks chronological age, DNA methylation changes relevant to biological age are expected to gradually dissociate from chronological age, mirroring the increased heterogeneity in health status at older ages. SN - 1474-760X UR - https://doi.org/10.1186/s13059-016-1053-6 DO - 10.1186/s13059-016-1053-6 ID - Slieker2016 ER -