Fig. 1

Distribution and heritability of adiposity phenotypes. a Scatterplot matrix showing the distribution and correlation between six adiposity measures in 3666 twins. The distribution of each phenotype (prior to normalisation) is shown along the diagonal. The lower panel shows scatterplots for each pair of adiposity phenotypes, and the upper panel denotes the coefficients of determination. b Heritability of six adiposity measures in the TwinsUK cohort, as well as visceral fat measures in three independent cohorts: Framingham [39], Quebec [41] and Heritage [40]. The total variance of each adiposity phenotype is decomposed into variance components attributed to additive genetics (A) or narrow-sense heritability (h ²), common environment (C) and unique environment (E)