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Fig. 2 | Genome Biology

Fig. 2

From: Novel regional age-associated DNA methylation changes within human common disease-associated loci

Fig. 2

Chromatin segmentation enrichment. a Overlap with a-DMRs and GWAS LD blocks for ENCODE ChromHMM [30] genome segmentation from ENCODE in nine tissues (data via and graph adapted from Epiexplorer [85]). Strong poised promoter enrichment seen. Observed versus expected for the GWAS LD block regions. b Overlap with a-DMRs and LD blocks for combined genome segmentation from ENCODE (ChromHMM [30] and Segway [31]) in six tissues. Strong enrichment for enhancers is evident. Sphere size is proportional to genomic space. TSS predicted promoter region including transcription start site, PF predicted promoter flanking region, E predicted enhancer, WE predicted weak enhancer or open chromatin cis regulatory element, CTCF CTCF enriched element, T predicted transcribed region, R predicted repressed or low activity region

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