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Table 2 Molecular readers of chromatin modifications

From: The epigenome: the next substrate for engineering

Reader domain scheme Modifications Example proteins
Individual domains
Methylation
 Chromo H3K4me2/3 CHD1
H3K9me2/3 HP1, CDY1
H3K27me3, H3K9me3 PC1/PC2/PC/LHP1
H3K36me3 MSL3
 Tudor H3K4me3/H4K20me3 JMJD2A
H4K20me2 PHF20
 MBT H3K4me1/ H4K20me1 PHF20L1
H4K20me1/2, H3K20me, H3K9me L3MBTL1
 PHD H3K4me3 TAF3
H3K4me2/3 ING2, BPTF/dmNURF301
H3K9me3 CHD4
Acetylation
 Bromodomain H4K16ac GCN5
H3K23ac TRIM24
H3ac, H4ac, H4K16ac P/CAF
Phosphorylation
 14-3-3 H3S10ph, H3S28p 14-3-3 ζ
Multisite binding
 Double tudor domain H3K4me2, H3K9me2, H4K20me2 53BP1
 Hybrid tudor domains (HTDs) H3K4me2/3, H4K20me2/3 JMJD2A
 Chromodomain Y-chromosome (CDY) [74] H3K9me3, H3K27me3  
Multivalent binding
 Bromo + Bromo H4K5ac + H4K12ac TAF1 (subunit of TFIID)
 PHD + Bromo H3K4me3 + H4K16ac BPTF
H3K9ac/H3K12ac + H3K4me3 TFIID
 Tudor + Bromo H3K9ac/H3K14ac + H3K4me3 SAGA complex
  1. Other useful references and guides [4, 140142]