Fig. 4

Determining intracellular circuits from known and in silico discovered networks. a Heatmap showing cell vs. cell correlation across a circuit scaled such that the maximum of both STA & PEA measurements are 1. The circuit is regulated by CASP8, with gates along the top indicating CASP8_P detection (white) or lack thereof (black) and time point (0 hr = purple, 24 hr = green, 48 hr = blue). The two major clusters are labeled 1 (red) and 2 (blue). b–d Changes in the Spearman correlation network from the known CASP8 circuit measured at 0, 24, and 48 hr, nodes grouped by edges. Edges represent correlations greater than 0.3 between CASP8 network and other targets. Red text indicates protein; black text indicates RNA; number of edges indicated by node size; colored boxes adjacent to the clusters indicate the time points for which a correlation coefficient greater than 0.3 exists between the target and the CASP8 network