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Fig. 1 | Genome Biology

Fig. 1

From: DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer

Fig. 1

APOBEC3 mutational signatures and associated genes in breast cancer subtypes. a Violin plots showing APOBEC3 mutagenesis fold enrichment. The purple diamond represents the median in each subtype. b Boxplots showing percentage of ‘APOBEC high’ (red) and ‘APOBEC low’ (blue) samples in each subtype. Asterisks represent a significant p value <0.05 from pairwise post hoc tests. c Single-nucleotide variants (SNVs) and SCNAs associated with ‘APOBEC high’ tumour samples. Bars denote proportion of ‘APOBEC high’ (red) and ‘APOBEC low’ (blue) samples harbouring mutation. Amplification and loss refer to ≥2× ploidy and ≤1 copy number relative to ploidy, respectively. An asterisk denotes significant association in subtype (q < 0.1 by permutation test, corrected for analysis of multiple genes by the Benjamini–Hochberg method). Note differing scales used on the y-axis. Lum luminal

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