Fig. 4

Evidence for schizophrenia-associated differential DNA methylation within genome-wide association study (GWAS)-nominated genomic regions. A Manhattan plot of an example genomic region (chr10:104423800-105165583) identified in the recent GWAS of schizophrenia [2] illustrates the location (x-axis) of genetic variants and Illumina 450 K probes against their significance with schizophrenia (y-axis; −log10 P value). Gene locations (exons and introns) are depicted above the Manhattan plot. Red diamonds depict GWAS results, green circles depict results from our phase 1 schizophrenia EWAS, and blue triangles depict results from our schizophrenia polygenic risk score EWAS