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Fig. 1 | Genome Biology

Fig. 1

From: An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease

Fig. 1

Intrinsic epigenetic age acceleration in Caucasians and Hispanics. a-d DNA methylation age (y-axis) versus chronological age (x-axis) in (a) Women’s Health Initiative, (b) blood data from PEG, (c) dataset 5, (d) saliva data from PEG. Dots corresponds to participants and are colored by ethnic group (gray = Caucasian, blue = Hispanic). The gray line depicts a spline regression line through Caucasians. We define two measures of age acceleration based on DNAm age. e-g The bar plots relate the universal measure of epigenetic age acceleration to race/ethnicity, which is defined as residual to the spline regression line through Caucasians, i.e. the vertical distance of a point from the line. By definition, the mean age acceleration in Caucasians is zero. h, m Results after combining the three blood datasets using Stouffer’s meta-analysis method. i Age acceleration residual versus ethnicity in the saliva data from PEG. j-m The y-axis reports the mean value of IEAA, which is defined as residual from a multivariate regression model that regresses DNAm age on age and several measures of blood cell counts. Each bar plot reports 1 standard error and the p value from a group comparison test (ANOVA). n Age acceleration in blood versus age acceleration in saliva for the subset of PEG participants for whom both data were available

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