Skip to main content
Fig. 2 | Genome Biology

Fig. 2

From: Selected heterozygosity at cis-regulatory sequences increases the expression homogeneity of a cell population in humans

Fig. 2

Low expression variation notwithstanding high regulatory sequence divergence at balanced SNPs. a The distribution of allelic imbalance calculated as the ratio of two alleles from the reads of chromatin accessibility for the balanced (red) or control (black) SNPs at heterozygous loci. In each cell type, the imbalance measures were normalized by subtracting the median of the control SNPs. Colored squares indicate the median point of the distribution and the box extends from the 30th to 70th percentile. b Allelic imbalance in chromatin accessibility (left) and allelic divergence in TF motif sequences (right) as a function of the Tajima’s D of the footprint SNPs. A higher motif divergence reflects more unique motifs for each allele. c Significance of expression quantitative trait loci (eQTL) mapping in lymphoblastoid (LCL), skin, and adipose cells according to the selection strengths at the regulatory SNPs. The red dotted lines denote an adjusted P value of 0.05. d The distribution of the coefficients of determination (R 2; top) and the P value (bottom) from a linear regression between the genotype of the balanced SNPs and the expression level of their target genes in whole-genome sequenced samples. The red vertical line indicates the adjusted P value of 0.05

Back to article page