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Table 4 Significantly over-represented biological pathways and candidate genes identified in DBA/1J

From: Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations

Pathway name Database p value (corrected) Candidate genes
Cell adhesion molecules (CAMs) KEGG 3.98 × 10–4 Esam, H2-M10, H2-M10, H2-T22, Itga9, Sdc3
Type I diabetes mellitus KEGG 7.54 × 10–3 H2-M10, H2-M10, H2-T22
Graft-versus-host disease KEGG 7.59 × 10–3 H2-M10, H2-M10, H2-T22
Autoimmune thyroid disease KEGG 8.55 × 10–3 H2-M10, H2-M10, H2-T22
Allograft rejection KEGG 1.01 × 10–2 H2-M10, H2-M10, H2-T22
Antigen processing and presentation KEGG 1.06 × 10–2 H2-M10, H2-M10, H2-T22
Viral myocarditis KEGG 1.14 × 10–2 H2-M10, H2-M10, H2-T22
Endocytosis KEGG 3.07 × 10–2 Arap3, H2-M10, H2-M10, H2-T22
Linoleic acid metabolism KEGG 4.49 × 10–2 Cyp2c44, Cyp2c50
Cytokine-cytokine receptor interaction KEGG 4.73 × 10–2 Il10ra, Il28ra, Tnfrsf1b, Tnfrsf8
  1. Candidate genes are genes that are found in the over-represented pathways and which contained a missense, deleterious SNP found in DBA/1J and not in DBA/2J or FVB/NJ. Corrected p values were calculated using the Benjamini–Hochberg method
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Genome Biology

ISSN: 1474-760X

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