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Table 4 Significantly over-represented biological pathways and candidate genes identified in DBA/1J

From: Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations

Pathway name

Database

p value (corrected)

Candidate genes

Cell adhesion molecules (CAMs)

KEGG

3.98 × 10–4

Esam, H2-M10, H2-M10, H2-T22, Itga9, Sdc3

Type I diabetes mellitus

KEGG

7.54 × 10–3

H2-M10, H2-M10, H2-T22

Graft-versus-host disease

KEGG

7.59 × 10–3

H2-M10, H2-M10, H2-T22

Autoimmune thyroid disease

KEGG

8.55 × 10–3

H2-M10, H2-M10, H2-T22

Allograft rejection

KEGG

1.01 × 10–2

H2-M10, H2-M10, H2-T22

Antigen processing and presentation

KEGG

1.06 × 10–2

H2-M10, H2-M10, H2-T22

Viral myocarditis

KEGG

1.14 × 10–2

H2-M10, H2-M10, H2-T22

Endocytosis

KEGG

3.07 × 10–2

Arap3, H2-M10, H2-M10, H2-T22

Linoleic acid metabolism

KEGG

4.49 × 10–2

Cyp2c44, Cyp2c50

Cytokine-cytokine receptor interaction

KEGG

4.73 × 10–2

Il10ra, Il28ra, Tnfrsf1b, Tnfrsf8

  1. Candidate genes are genes that are found in the over-represented pathways and which contained a missense, deleterious SNP found in DBA/1J and not in DBA/2J or FVB/NJ. Corrected p values were calculated using the Benjamini–Hochberg method