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Table 3 Significantly over-represented biological pathways and candidate genes identified in RF/J

From: Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations

Pathway name

Database

p value (corrected)

Candidate genes

Degradation of the extracellular matrix

REACTOME

4.91 × 10–3

Adam15, Cdh1, Col4a4, Eln, Mmp11

Extracellular matrix organization

REACTOME

1.15 × 10–2

Adam15, Cdh1, Col4a4, Eln, Lama3, Mmp11

ECM-receptor interaction

KEGG

1.32 × 10–2

Col4a4, Itga10, Itga7, Lama3

Pathways in cancer

KEGG

4.56 × 10–2

Cdh1, Col4a4, Fas, Kit, Lama3, Msh3

  1. Candidate genes are those that are found in the respective pathways and contained a missense SNP private to the RF/J strain. Corrected p values are based on the Benjamini–Hochberg method
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Genome Biology

ISSN: 1474-760X

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