TY - JOUR AU - Nelson, David M. AU - Jaber-Hijazi, Farah AU - Cole, John J. AU - Robertson, Neil A. AU - Pawlikowski, Jeffrey S. AU - Norris, Kevin T. AU - Criscione, Steven W. AU - Pchelintsev, Nikolay A. AU - Piscitello, Desiree AU - Stong, Nicholas AU - Rai, Taranjit Singh AU - McBryan, Tony AU - Otte, Gabriel L. AU - Nixon, Colin AU - Clark, William AU - Riethman, Harold AU - Wu, Hong AU - Schotta, Gunnar AU - Garcia, Benjamin A. AU - Neretti, Nicola AU - Baird, Duncan M. AU - Berger, Shelley L. AU - Adams, Peter D. PY - 2016 DA - 2016/07/25 TI - Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability JO - Genome Biology SP - 158 VL - 17 IS - 1 AB - Histone modification H4K20me3 and its methyltransferase SUV420H2 have been implicated in suppression of tumorigenesis. The underlying mechanism is unclear, although H4K20me3 abundance increases during cellular senescence, a stable proliferation arrest and tumor suppressor process, triggered by diverse molecular cues, including activated oncogenes. Here, we investigate the function of H4K20me3 in senescence and tumor suppression. SN - 1474-760X UR - https://doi.org/10.1186/s13059-016-1017-x DO - 10.1186/s13059-016-1017-x ID - Nelson2016 ER -