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Table 1 Group summaries for the number of singleton non-synonymous candidate variants in OMIM disease-associated genes among IGM’s 5965 samples

From: Unequal representation of genetic variation across ancestry groups creates healthcare inequality in the application of precision medicine

Geographic ancestry / ethnic group Number of individuals Number of singletons using internal reference cohort (n = 5,965) Number of singletons using internal and ExAC reference cohorts (n = 66,217)
Median Mean SD Median Mean SD
European 5,094 15 15.2 5.0 6 6.6 3.0
African (African American) 505 29 29.7 8.3 9 9.9 4.8
Latino ethnicity 93 28 28.3 6.0 10 10.9 5.5
East Asian 61 51 50.2 9.1 12 12.3 4.2
South Asian 38 49.5 50.5 7.4 12 12.7 3.8
Unassigned 174 24 22.7 11.9 8 8.3 5.8
  1. Data reflect using only the internal reference cohort and then subsequently supplementing the IGM internal reference cohort with variant information from the ExAC reference cohort of 60,252 controls of convenience
  2. SD standard deviation